Study of Impact of Pre-Implantation Genetic Screening on IVF Procedures

Debated in Parliament on 3 Nov 2020.

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Louis Ng Kok Kwang asked the Ministry of Health if it is aware of studies indicating that Pre-Implantation Genetic Screening (PGS) may negatively affect IVF success rates such as implantation, pregnancy, and live births.
Minister Gan Kim Yong noted that published studies on PGS show mixed findings, with some reporting improved outcomes in selected groups while others found no improvement or even lower success rates in IVF procedures.
He cited specific examples, including a 2013 trial showing higher implantation and delivery rates with PGS, a 2018 trial finding no increase in live birth rates for older women, and a 2011 meta-analysis indicating lower live birth and pregnancy rates with PGS.
The Minister highlighted limitations in existing studies, such as suboptimal recruitment, which contribute to ongoing debate about PGS's clinical efficacy.
He concluded that more data is needed before any definitive conclusion can be made on the clinical effectiveness of PGS in IVF procedures.

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Louis Ng Kok Kwang

Mr Louis Ng Kok Kwang asked the Minister for Health whether the Ministry is aware of any scientific studies which suggest that the Pre-Implantation Genetic Screening will negatively affect the success rates of embryo implantation, pregnancy and live births for people who go through in-vitro fertilization (IVF).

Gan Kim Yong

Published studies on Pre-Implantation Genetic Screening (PGS) have reported mixed findings, ranging from those with favourable outcomes for PGS in selected patient groups, to those that find that PGS does not improve, or may even result in lower, in-vitro fertilization success rates. For example, a 2013 randomised controlled trial (RCT) found that the sustained implantation rate and delivery rate per cycle were significantly higher in the PGS group compared to the control group. However, a 2018 RCT found that PGS did not increase live birth rates in women of advanced maternal age, while a 2011 meta-analysis of RCTs showed lower live birth and ongoing pregnancy rates in the PGS group compared to the control group.

However, given the limitations of the studies (such as suboptimal recruitment), the clinical efficacy of PGS remains widely debated. More data is needed before we can conclude on the clinical efficacy of PGS.

Summary written by AI (learn more)

Louis Ng Kok Kwang asked the Ministry of Health if it is aware of studies indicating that Pre-Implantation Genetic Screening (PGS) may negatively affect IVF success rates such as implantation, pregnancy, and live births.
Minister Gan Kim Yong noted that published studies on PGS show mixed findings, with some reporting improved outcomes in selected groups while others found no improvement or even lower success rates in IVF procedures.
He cited specific examples, including a 2013 trial showing higher implantation and delivery rates with PGS, a 2018 trial finding no increase in live birth rates for older women, and a 2011 meta-analysis indicating lower live birth and pregnancy rates with PGS.
The Minister highlighted limitations in existing studies, such as suboptimal recruitment, which contribute to ongoing debate about PGS's clinical efficacy.
He concluded that more data is needed before any definitive conclusion can be made on the clinical effectiveness of PGS in IVF procedures.

Questions identified by AI (learn more)

Study of Impact of Pre-Implantation Genetic Screening on IVF Procedures | PAPERCUTS

Study of Impact of Pre-Implantation Genetic Screening on IVF Procedures

Debated in Parliament on 3 Nov 2020.

Summary written by AI (learn more)

Louis Ng Kok Kwang asked the Ministry of Health if it is aware of studies indicating that Pre-Implantation Genetic Screening (PGS) may negatively affect IVF success rates such as implantation, pregnancy, and live births.
Minister Gan Kim Yong noted that published studies on PGS show mixed findings, with some reporting improved outcomes in selected groups while others found no improvement or even lower success rates in IVF procedures.
He cited specific examples, including a 2013 trial showing higher implantation and delivery rates with PGS, a 2018 trial finding no increase in live birth rates for older women, and a 2011 meta-analysis indicating lower live birth and pregnancy rates with PGS.
The Minister highlighted limitations in existing studies, such as suboptimal recruitment, which contribute to ongoing debate about PGS's clinical efficacy.
He concluded that more data is needed before any definitive conclusion can be made on the clinical effectiveness of PGS in IVF procedures.

Questions identified by AI (learn more)

Full Transcript

Louis Ng Kok Kwang

Gan Kim Yong

Summary written by AI (learn more)

Louis Ng Kok Kwang asked the Ministry of Health if it is aware of studies indicating that Pre-Implantation Genetic Screening (PGS) may negatively affect IVF success rates such as implantation, pregnancy, and live births.
Minister Gan Kim Yong noted that published studies on PGS show mixed findings, with some reporting improved outcomes in selected groups while others found no improvement or even lower success rates in IVF procedures.
He cited specific examples, including a 2013 trial showing higher implantation and delivery rates with PGS, a 2018 trial finding no increase in live birth rates for older women, and a 2011 meta-analysis indicating lower live birth and pregnancy rates with PGS.
The Minister highlighted limitations in existing studies, such as suboptimal recruitment, which contribute to ongoing debate about PGS's clinical efficacy.
He concluded that more data is needed before any definitive conclusion can be made on the clinical effectiveness of PGS in IVF procedures.

Questions identified by AI (learn more)

Study of Impact of Pre-Implantation Genetic Screening on IVF Procedures

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Questions Identified

Full Transcript

Louis Ng Kok Kwang

Gan Kim Yong

Summary

Questions Identified

Study of Impact of Pre-Implantation Genetic Screening on IVF Procedures

Summary

Questions Identified

Full Transcript

Louis Ng Kok Kwang

Gan Kim Yong

Summary

Questions Identified